And experiments, when deemed to be failures... are discontinued. 
- —Mr. Sinister
Appearing in "Man and Monster: Conclusion"
Featured Characters:
Supporting Characters:
- Template:Flash
Antagonists:
- Template:Flash
- The Children (First appearance)
- Template:Flash
- Nine unnamed members
- Megacorp
- John Sublime/"Michael Grand"
- Mr. Tomes
Other Characters:
- Constrictor (Frank Schlichting)
- Typhoid Mary (Mary Walker)
- Peepers (Peter Quinn)
- Professor (Andre Thorton) (Photo)
- Wolverine (Logan) (Appears on screen)
- Fantomex (Jean-Phillipe) (Appears on screen)
- Agent Zero (David North) (Appears on screen)
- Dr. Cecilia Reyes (Appears on screen)
- Weapon X Program (Appears on screen)
- Director (Brent Jackson) (Appears on screen)
- Sauron (Karl Lykos) (Appears on screen)
- X-Men (Mentioned)
- Jean Grey (Mentioned)
- Cable (Nate Summers) (Mentioned)
- U-Men (Mentioned)
Locations:
- Satan's Circus
- Sinister's Castle
Items:
Vehicles:
Synopsis for "Man and Monster: Conclusion"
- Synopsis not yet written
Notes
- This is the final issue of Weapon X (2nd series). At the end of the issue, writer Frank Tieri suggests that fans write letters to Marvel if they want this series to continue and find out how the series truly ends. So far, lots of angry fans did write many letters and e-mails to Marvel Comics. In an interview, Tieri has explained that he can wrap everything up in a 6-issue mini-series and will even write the first issue for free if he has too. Marvel has apparently read all the fan mail and now a limited series was in suggestion, but there is still no confirmation. However, after M-Day, it is unlikely the story will continue. Some of it, although not enough of it, has been told in other series.
- At the end of this issue, Sabretooth receives a note saying Brotherhood. He would next be seen in X-Men (2nd series) as a member of the new Brotherhood.