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Fiancée of multi-millionaire industrialist Edward Vance. Romantically involved with Jamie Madrox, she was the one who had hired the assassin Clay to prevent Madrox from interfering in her plans to take control of the Chicago crime syndicate. Sheila was ultimately killed after she was revealed to be a self-styled highly evolved mutant.
- 4 Appearances of Sheila DeSoto (Earth-616)
- Media Sheila DeSoto (Earth-616) was Mentioned in
- 1 Images featuring Sheila DeSoto (Earth-616)
- Quotations by or about Sheila DeSoto (Earth-616)
- Character Gallery: Sheila DeSoto (Earth-616)
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