Doctor Octopus of the year 2099 sent Hobgoblin after a piece of the fragment of the Tablet of Order and Chaos, and hired Scorpion to steal another with the promise of curing him. After their defeats, she caught Spider-Man infiltrating her lair when he was looking for a tablet fragment he was supposed to collect. She planned on using the energy of the fragment to power a Condensed Matter Reactor to wreak havoc upon the city. However, Spider-Man managed to shut down her reactor and defeat her in combat.
With the tablet fragment, she was able to mentally control any machinery.
Serena is amongst the greatest scientists in Nueva York (she is a genius compared even to other great scientists of 2099, as she managed to create a machine to harness the powers of a mystical fragment). She is also highly capable in the fields of technology, genetics, and very knowledgeable in the history of the Heroic Age.
Dr. Octopus has the strength of an average woman who exercises regularly. And while wearing her Octo-suit, it is assumed she can press around 20 tons
While her intellect is one of her greatest assets, it is also one of her greatest weaknesses; as her arrogance makes her think that no one can match her in any battle, of any sort. Also, she apparently has a short temper; During her encounter with Miguel, every time they spoke to each other, she got angered to the point where she was attempting to kill him.
Has countless robot/mutant hybrids and machines of mass destruction at her disposal. Also, her Octo-suit gives her six additional arms which allow her to conduct multiple experiments at once or take down numerous foes
She walks very fast on her tentacles.
Her tentacles make her a formidable opponent.
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