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When the United States Army recruited Ted Sallis into "Project Sulfur," which sought a means to survive bio-chemical warfare, Sallis developed "Serum SO-2," which granted immunity to all known toxic biochemicals, but its mutagenic effects would have transformed people into monsters.

Ted's friend, the free-spirited girl Sainte-Cloud, convinced him to denounce the Project, shutting it down before any serum was produced. Ted proposed to Sainte-Cloud, but she refused due to their many differences[1].

Years later, in a weird twist of fate, a Man-Thing-shaped candle (created after his New York rampage) was drugged and given to Sainte-Cloud by her jilted lover Chuck, causing her to see Man-Thing hallucinations; exposed to the drug himself, a terrified Chuck badly burnt his face on the candle[1].

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