Rapture is a highly additive drug created by Alchemax. The company did not want one of it's best scientist Miguel O'Hara to quit. At his farewell dinner, Tyler Stone spikes his drink with Rapture, a drug that bonds with your DNA to make you addicted for life. Alchemax is the only supplier of Rapture, so Miguel has to stay working for them or suffer horrible, unending withdrawal pains. Miguel instead decides to restore his DNA from a stored version, but his DNA gets mixed with spider DNA turning him into Spider-Man of 2099. [1]


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