- Sometimes sacrifices must be made in the name of science.
- -- Doc Ock src
Doctor Octopus kidnapped Felicia Hardy for ransom from Felicia's mother Anastasia, who did not have patience to fund Ock's experiments before he was a villain. Octopus later became a member of the Insidious Six.
On one occasion, Octopus wiped Spider-Man's memory and made him believe the two were partners-in-crime. On this occasion he was defeated by a small girl named Taina. He later appeared to blackmail Anastasia Hardy, aware that Anastasia Hardy's husband, John Hardesky, was a cat burglar known as the Cat and threatened to release this information if she did not pay him.
Ock was one of the villains chosen to come to Battleworld and fight. When the Doctor's kingdom, Octavia, was captured by Doctor Doom, Octavius went to work for Red Skull and Alistair Smythe. When Doom stole the Beyonder's powers, he sent Ock and the other villains back to Earth and erased their memories.
- Doctor Octopus appears in Spider-Man: The Animated Series, voiced by Efrem Zimbalist Jr. who gave the character a thick Germanic accent (Efrem also voiced the character in the Playstation and N64 Spider-Man game.
- In the series finale of this show, Doctor Octopus does not appear, but among the other Spider-Men from different realities was a Spider-Man with metallic tentacles and sunglasses like Doc Ock's. He explained it was a "souvenir from my last fight with Doctor Octopus".
- 16 Appearances of Otto Octavius (Earth-92131)
- Minor Appearances of Otto Octavius (Earth-92131)
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