Through her mother's bloodline, Nina became part of a long family curse. This curse had originated with Nina's 18th century ancestor Grigori, who had been tainted by the Darkhold, a grimoire of black magic, and was subsequently bitten by a werewolf who served Dracula. Because of this, all the descendants of Grigori were cursed to become a werewolf upon their 18th birthday. Nina's mother Lissa Russell was a victim of the curse until an altercation with a sorcerer named Glitternight altered her standing and she was freed from being a werewolf. Lissa then married a wealthy business tycoon named Mr. Price and gave birth to Nina. Although her mother was able to alter the curse's path against her, the curse continued its course to Nina. At some point Nina was attacked by a vampire who attempted to change her into the undead. This attack altered the curse for Nina somewhat and caused her to become both werewolf and vampire in one. By day Nina Price seems to be a normal human, but once the sun goes down she becomes a vampire. Due to the werewolf's bite, Nina became a white wolf during the full moon, and she used her father's money and status to reserve a zoo or park, in which she would cage herself until the full moon was over and she was no longer an animal (so she would not hurt innocents). However, Nina had no problem using her supernatural abilities to harm criminals, as she found them acceptable targets for her vampiric thirsts, feeding on rapists and thieves once the sun went down.
Falling in a trap set by S.H.I.E.L.D. during an adventure with her uncle Jack, Nina soon after became a reluctant member of Nick Fury's Howling Commandos. Working at a secret military installation called Area 13, Nina was placed as part of a supernatural team working for the government set to handle situations that dealt with more of the macabre side of life, the team being called the Paranormal Containment Unit. During her time there she was partnered with another werewolf named Warwolf and fellow vampire Lilith, the daughter of Dracula.
Nina is a hybrid of a vampire and a werewolf, and possesses the abilities of both after sunset. Her vampire powers make her super-humanly strong and fast, and unable to cast a reflection (which makes it impossible for people to take her picture at night). She can hypnotize people with her stare, an ability she often uses to immobilize her prey. Like a normal vampire, she must feed on human blood, but she focuses her hunger on criminals. Due to her hybrid nature, sunlight is not lethal to Nina. She is also not affected by wooden stakes to her heart. She heals amazingly fast from the most serious injuries.
She is also imbued with the power of lycanthropy, and when the moon is full, she becomes an Arctic timber wolf. Unlike her uncle Jack, she doesn't have a humanoid wolf form. In this state, Nina has superhuman senses of hearing and smell, and deadly fangs and claws. She is overwhelmed by the wolf's feral instincts, and often shuts herself away from others to prevent herself from killing innocent people.
A child of wealth and privilege, Nina received the best education possible. She is exceptionally intelligent and is also fluent in several languages, including Italian and French.
Superhuman: As a supernatural creature, Nina Price possesses enhanced strength, enabling her to lift/press in excess of 800 lbs. The full limit of her strength levels are unknown.
Nina has stated that silver weapons could work on her.
Nina Price does not actually refer to herself as "Vampire by Night". The name is attributed to her to draw a parallel between herself and her uncle, Jack Russell, who at times, has been referred to as Werewolf by Night.