Mister Sinister's life was similar to his Earth-616 counterpart up to a certain, unspecified point.
Mister Sinister is a master of genetic manipulation, and created Madelyne Pryor to breed with Havok and produce a powerful child. Years ago, he had Gambit steal two children from a fortified facility, of whom the boy was artificially grown into the X-Man, and the girl was left with Gambit, to be raised as his "daughter" Raven. Sinister originally wanted to kill the girl, but Gambit protested and turned to mist (he had just been changed into a vampire), and Sinister relented. At some point (whether before or after this incident is unknown), Sinister joined forces with Xavier in a plan to control the world. However, in the final battle, Sinister realized that Xavier was going to destroy the conditions he needed for his genetic manipulations of mutants, and he protested, whereupon Xavier blasted him, apparently killing him.
Known Powers: Following genetic alteration by Apocalypse, Sinister possesses a wide array of powers. Over the years, Sinister has used the genetic material of other mutants to grant himself a vast array of powers.
- Regenerative Healing Factor: Mister Sinister is able to rapidly regenerate damaged or destroyed tissue with much greater speed and efficiency than an ordinary human. Sinister can fully heal from injuries that result in massive tissue damage or loss such as multiple gunshot wounds, slashes, puncture wounds, broken bones, and severe burns within a matter of moments.
Superhuman Stamina: Mister Sinister's muscles produce considerably less fatigue toxins than the muscles of ordinary humans. He can exert himself at peak capacity for about 24 hours before fatigue begins to affect him.
Superhuman Strength possesses superhuman strength, which may be a product of his shapeshifting.Sinister is able to lift/press about 10 tons.
Superhuman Reflexes: Mister Sinister's reflexes are enhanced to levels that are beyond the human body's natural limits.
Telepathy: He can read minds and project his own thoughts into the minds of others within a radius of 250 miles (on Earth). With extreme effort he can greatly extend that radius.
- Mental Paralysis: ability to induce temporary mental or physical paralysis
- Mind Control: capable of controlling the minds of others but only one at a time and if the target is in his physical presence.
- Dilate Power: ability to mentally paralyze a foe he's touching and the ability to psionically "turn off" the superpowers of any mutant.
Telekinesis: possesses telekinetic abilities enabling him to levitate and manipulate living beings, inanimate objects, and to some extent energy, psionically. He can “lift” as much as 10 tons of weight and possibly even more and can enable himself to “fly” at great speed.
Concussive Blasts: can fire blasts of concussive force from his hands or from the dimaond-shaped scarlet mark on his forehead.
Genius-Level Geneticist: Sinister is a genius and a geneticist of the highest order, able to predict genetic mutations and splice DNA. It is quite probable his powers are the result of self-experimentation. He can also produce large amounts of clones; he has done so with Jean Grey.
Master Surgeon: He is a master surgeon.
Skilled Mechanical Engineer: having created devices that seem to have been taken from the tales of Jules Verne.
Master Manipulator: He possesses a good deal of knowledge in psychology, and is a skilled manipulator.
Many of his bases seem to have some quasi-biological properties, able to "grow" tentacles from a surface to hold a prisoner at Sinister's mental commands.
- 4 Appearances of Nathaniel Essex (Earth-1298)
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- 1 Quotations by or about Nathaniel Essex (Earth-1298)
- Character Gallery: Nathaniel Essex (Earth-1298)
- Characters killed by Mister Sinister
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