A special serum which inhibits and neutralizes mutant powers, and was planned to be used by the US Government to all the mutants, willingly or not. It was developed based on the genetic structure of Jimmy, who possessed the ability to negate mutant abilities in his vicinity. Although publicly proclaimed as a willing cure for mutants who sought to eliminate their dangerous powers, the cure was also weaponized to use against dangerous mutants.
It is implied that the cure's effects were only short-term, as Magneto was injected with the cure and later showed signs of regaining his powers, and Rogue regained her powers at some point after taking it herself, but it is unclear if other factors affected this turn of events, such as Magneto's age or Rogue's sheer power potential.
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