- When I was little I had a pair of red rubber boots. My boots took me places. One day they got lost. I thought they were hiding under my bed. But they're gone. I miss them. All of them. One of us is tender one of us is not. One of us take vengeance. All four tied in a knot.
- -- Typhoid Mary src
Her condition was accidentally caused by a pre-Daredevil Matt Murdock. He had tracked a villain down to the brothel where Mary Walker worked. He attacked the man, but to his surprise, the girls working there came at him. Panicking, he lashed out, knocking Mary out the window. It was at this moment Mary became Typhoid Mary, vowing no man would ever hurt her again. However, she would imply that she was a victim of child abuse.
Suffering from dissociative identity disorder, Mary Walker has two other abnormal personalities in addition to her seemingly healthy one. Her "Mary" personality is a timid, quiet, pacifist; her "Typhoid" personality is adventurous, lustful, and violent; and her "Bloody Mary" persona is brutal, sadistic, and hates all men. Mary once claimed that there was a fourth personality, who is 'lost,' but it has not since been mentioned. Aside from highly developed martial arts skills, Walker also possesses telekinetic powers and, more dangerously, pyrokinesis, the ability to set people or objects in her immediate vicinity aflame.
A favorite pawn of the Kingpin, Typhoid frequently battled and had a love-hate relationship with Daredevil before disappearing. Through hypnosis, the abnormal and psychotic personalities (Typhoid: the adventurous sociopath, and Bloody Mary: the homicidal psychopath) were suppressed from Mary Walker's consciousness, and she began to lead a normal life, becoming a soap opera star. Mary Jane Watson and battled Spider-Man when Bloody Mary resurfaced and she began killing men who committed domestic abuse. With the web-slinger's help, Mary regained control and voluntarily turned herself in to the police for treatment.
At one point, Mary was confined to a mental institution where each personality hired a mercenary. Mary Walker hired Deadpool to kill her, Typhoid Mary hired Deadpool to break her out, and Bloody Mary hired The Vamp/Animus to break her out to resume a killing spree. Deadpool defeated the Vamp/Animus but refused to kill Mary Walker, allowing the Typhoid personality to become dominant. Typhoid and Deadpool had a few adventures together, but when Deadpool pushed her out of a window, her memories of Daredevil kicking her out of the brothel window returned. She and Deadpool traveled to New York City to confront Daredevil but Deadpool became upset when he found out that she had also been killing people from her past who couldn't defend themselves against her. He and Daredevil defeated her but, against Daredevil's pleas, Deadpool insisted on trying to rehabilitate her himself. Mary however, discovered Deadpool's infatuation with Siryn and, using an Image Inducer, tricked Deadpool into sleeping with her. When Deadpool discovered the ruse, he was so shocked and betrayed that he gave up trying to help Mary. 
Agent of Chaos
Following the Kingpin's fall from power and being left in a coma near death, he recovered and started rising back to power, taking out his enemies. To distract Daredevil while he retook his criminal empire, the Kingpin paid a visit to Walker at her show and with a blunt slap released the abnormal personalities. After confronting Daredevil in his secret identity (Matt Murdock) and setting him on fire, his bodyguards Luke Cage and Jessica Jones managed to take her down. Mary was imprisoned on 'The Raft', a maximum security prison for super-powered criminals.
Electro later led an attack on the Raft, helping the prisoners break out. While the Avengers arrived and managed to stop some of the prisoners, Mary managed to escape and briefly worked for the Kingpin once more.
Mary was one of the few mutants to retain her powers following M-Day, but she was not initially included in the official record of the remaining mutants (the so-called "199th" still empowered mutant).
At some point after the events of the superhuman Civil War, Mary was found by Henry Peter Gyrich and recruited into the Initiative program. The reason why she joined the Initiative was because she couldn't merge or block out her four personalities, so she offered to join in exchange for a pardon and to help integrate her fractured mind, which was still a work in progress.
Technically not existing in any official capacity, Mary's true identity was made classified and she was given the codename of "Mutant Zero". According to Dr. Leonard Samson, Mutant Zero was still mentally unstable and that referencing any of her other identities could have led to a period of instability. Mutant Zero was inducted into the Initiative's black ops team, the Shadow Initiative, but due to her mental instability she could only be "activated" once per mission.
When Taskmaster was appointed as field leader of the Shadow Initiative, he sensed something familiar about Mutant Zero's body language (thanks to his superhuman ability), and initiated an impromptu sparring match with her to satisfy his curiosity. After witnessing her fighting style and provoking her into using her pyrokinesis, Taskmaster shattered her helmet's faceplate and revealed her as Typhoid Mary.
Later on Mary decided to work with Daredevil and The Hand to which she ended up fighting and burning Spider-Man. Later on when the heroes then broke into the revival of Bullseye she fought Spider-Man again and lost. In the end, it turns out that she was a sleeper agent for the Kingpin and was being controlled by him with subliminal messages.
Typhoid Mary is a mutant and possesses a number of psionic powers. Due to her mental illness, Mary's powers differ on which personality is 'in control'. As Mutant Zero, Mary appears to possess the same psionic powers utilized by both Typhoid and Bloody Mary. It is unknown whether the powers possessed by this personality are stronger than those of the "Bloody Mary" personality. Recent battles suggest they are more powerful, but take their toll on Mary when using them as a result of this increased strength.
- Telekinesis: She can levitate objects and people and can also project a telekinetic shield or force field. She can also release devastating force blasts. With this power, she can fly at great speed. She can levitate small objects over short distances (such as weapons of under 10 pounds; knives, razors, etc., which her "Bloody Mary" persona often gathered and assembled into improvised battle-armor.
- Telepathy: She can implant mental suggestions in the minds of others. She can induce sleep in weak-minded individuals and most animals. She has the power to seduce and make others fall in love with her using her mind.
Mary seems to be very skilled in martial arts and the use of edged weapons.
As Mutant Zero, Mary is equipped with a suit of full body armor that appears to enhance her physical strength and an arsenal of weapons, including guns and various blades.
- When Mary's personality changes, her physiology (heart rate, etc) changes also to the likes of a different person.
- 119 Appearances of Mary Walker (Earth-616)
- Media Mary Walker (Earth-616) was Mentioned in
- 20 Images featuring Mary Walker (Earth-616)
- 4 Quotations by or about Mary Walker (Earth-616)
- Character Gallery: Mary Walker (Earth-616)
- Fan-Art Gallery: Mary Walker (Earth-616)
- Unofficial Marvel Comics Reference HQ: Typhoid Mary
- Twisted Love - Typhoid Mary
- Typhoid Mary's Dojo
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