Dr. Martha Connors is a scientist at Empire State University Labs. She is an expert in biology along with her husband Dr. Curt Connors. They have a son Billy Connors who hangs about the Lab with them. Her husband Dr. Connors lost his arm in an accident has a functioning, mechanical prosthetic arm. Her husband is obsessed with uncovering the secrets of reptilian limb regeneration and creates a serum made of modified lizard DNA. He injects himself with it frequently to help re-grow his lost arm.

In a fight in the Lab between Spider Man and former electrician Max Dillon / Electro, one of the vials is hit by Electro's electricity, amplifying the DNA within the serum. As a result of injecting the altered Lizard serum, Connor's arm re-grows as expected. However, Connors is later fully transformed into the Lizard. In the Lizard's can't talk, yet he was also acts purely on animalistic instincts. The Lizard is extremely aggressive, shown attacking with little or no provocation, and even coming close to biting Billy. An antidote called a gene cleanser, developed by Spider-Man, Eddie, Gwen, & Dr. Martha Connors manages to restore back to his normal self.

When the alien symbiote is found on Colonel. John Jameson Shuttle it is taken to the ESU Labs to be studied by the Connors. The pair is ecstatic about the discovery and gives new hope to their lives and career. But after the robbery in which it gets attached to Spider-Man, they are distraught over the loss

Later the science department gains Dr. Miles Warren as a new member as Norman Osborn funds the research. Dr. Warren has been conducting mutagenic experiments on human test subjects; her husband threatens to inform the school board only for Dr. Warren to blackmail him with his own lizard experiments. Later after all their trouble's and losses Martha and Curtdecide to leave with Billy for the Florida, everglades to escape Warren's blackmail.

  • Martha Connors first appears in The Spectacular Spider-Man episode "Survival of the Fittest" voiced by Kath Soucie.

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