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Margaret Connors was the wife of Doctor Curt Connors and mother to their young son Billy.

When Curt tried to use the "neogenic recombinator" to re-grow his lost arm, he accidentally transformed into the Lizard. He kidnapped Margaret, and told her of his plan to turn everybody in New York City into beings like him. However, Spider-Man stopped him, saved him and he was returned to normal.

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