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Anansi is one of the Orishas, a race of extra-dimensional beings still worshiped as gods by the tribes of Africa and by modern-day practitioners of Voodoo.
According to Ezekiel Sims and the Ashanti tribe in Ghana, Anansi was the first Spider-Man, using his spider-powers to traverse Africa and see all there was to see. Desiring further enlightenment, Anansi struck a bargain with the sky god Nyame, offering his eternal service in return for enlightenment and vanished from the mortal world, his power and knowledge transmitted into spiders everywhere across a Great Web.
Anansi's temple in Ghana was used by Spider-Man to defeat the totemic wasp entity Shathra, and was later the site of a duel between Ezekiel Sims and Peter Parker in order to appease the totemic spider deity called the Gatekeeper.