Agent Diana was an agent of S.H.I.E.L.D. She was hurt in an accident after trying to steal some organism that could attach itself to other organisms and became a mutated form of the organism herself then wanted revenge.
She found that Thaddeus Ross was in the hospital. However, she could not get close to him. She possessed a nurse, then she waited until Ross's daughter Betty left the room. When Betty left Hybrid went into the room, left nurse's body, and possessed the general.
As Ross, she went to Betty who saw her father waking up. She saw that his eyes were not right and started to fight him. She tried to call Bruce Banner but Hybrid possessed her.
They commandeered a submarine and entered the facility. However, they were captured by Jones. Hybrid understood that it was time to change the body, and by kissing Grey Hulk possessed him.
While being kicked out of the base, Gabriel revealed to She-Hulk the story of who Diana was and how did she became like that.
Hybrid tried to take control of the base using it as a weapon. She demanded that Gabriel transfer the control of all of S.H.I.E.L.D.'s nuclear silos to it or else she will flood the coast of California with massive waves. Gabriel denied and sent S.H.I.E.L.D. Cruisers to intercept the sea base. Hybrid sunk the cruisers using the facility's weapon, but this caused the reactor to overload, entering meltdown. The situation enraged Hybrid and Hulk's natural healing ability, combined with his anger, forced Hybrid out turning him into Green Hulk. Hybrid tried to possess Betty again, but Hulk punched her into unconsciousness.
She woke later and possessed a shark, swimming away before the facility exploded.
Hybrid was voiced by Dawnn Lewis.
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