A Black Hole is a region of spacetime exhibiting such strong gravitational effects that nothing not even particles and electromagnetic radiation such as light can escape from inside it. The theory of general relativity predicts that a sufficiently compact mass can deform spacetime to form a black hole.
- The Mutant Xorn was said to have a "Black Hole" in his head and the only thing keeping it in place was a metal helmet. The prospect of taking off his helmet was considered incredibly dangerous, nevermind the fact that it would only be dangerous to anything very close to his head. 
- Like his brother, Shen Xorn has a star for a brain. Shen's star manifested as a black hole. He lost them during M-Day, but after the Terrigen Mists hit Earth, Shen has seemingly regained his powers.
- While on vacation Greg Willis was sucked into a strange mini black hole. however is found hours later by his parents. After this Greg finds that he is able to manipulate the gravity around his body becoming the hero "Gravity".
- The Fantastic Four along with Thor and Iron Man, time-traveled to the future where the Black Celestial had built a weapon to destroy all reality so he could recreate the universe in his own image. The weapon was Galactus, who had his hunger for planets somehow amplified to the point where Galactus converted himself into a giant "black hole" which would, in time, suck up all matter in the universe, from all points of time. As this alternate future was encased in a time bubble, Galactus was able to eliminate this time line from happening by deploying the Ultimate Nullifier.
- In a distant future Xanth was on a mission to save his people and discovered the remains of the Voyager 2 space probe, launched from Earth centuries earlier. Interested in recovering the relic before it could be swallowed up in a black hole, but his ship was swallowed as well. He was mutated in the Black Hole becoming Ebon Seeker and arriving in the past of Earth-616 where he battled the Fantastic Four.
- Dazzler powers were boosted to cosmic levels and sent into a black hole to retrieve the wayward herald of Terrax for Galactus. 
- Oblivion gained power and a representational black hole began growing to overtake all of existence.
- The Elders of the Universe tried to murder Galactus on the Cone Nebula. Their plan was foiled by the Silver Surfer and a black hole swallowed a number of the Elders, with the others being punished by Galactus himself.
- In the Ultimate Universe, Zorn exploded into an un-proportionately large black hole that began to suck up everything within a few dozen miles.
- In Earth-14161, Vision died during the final battle with Dimitrios and his Machine Imperium at the Golden Knot being absorbed into Doombot's Black Hole.
- In Earth-14026, when Earth was ravaged and close to be destroyed by the Annihilation Wave, Uatu broke his vow of noninterference in assisting Earth's heroes by informing them about the Terminus device that can be use in opening a black hole to suck the Wave away and ending the galactic conflict.
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