At this moment no living thing in the universe will die. Not the lowliest bacteria nor grandest Celestial. While stars collapse and implode, blown to dust all that possesses "life" refuses oblivion. All of it lives on despite its destiny, in defiance of the engine of evolution that culls the weak. All of it, Wilson, but you. I am the only reason you live. And because Thanos decrees it, you will die. 
Appearing in "Part One: From Her to Eternity"
Featured Characters:
- Deadpool (Wade Wilson) (Main story and flashback)
- ⏴ Thanos ⏵
Supporting Characters:
- Mistress Death (Main story and flashback)
- Black Talon (Samuel Barone) (Main story and flashback)
Antagonists:
- Doctor Doom (Victor von Doom) (Only in flashback)
Other Characters:
- Unnamed Latverian Concierge (First appearance; dies)
- Cynthia von Doom (Mentioned)
- Doombots (Mentioned)
- Unnamed Sailor (First appearance)
- S.H.I.E.L.D. (Mentioned)
- Avengers (Only in flashback)
- Iron Man (Tony Stark) (Only in flashback)
- Thor (Only in flashback)
- Black Widow (Natasha Romanova) (Only in flashback)
- Spider-Woman (Jessica Drew) (Only in flashback)
- Captain America (Steve Rogers) (Only in flashback)
- Nick Fury (Mentioned)
- Avengers (Only in flashback)
- Zombies (Only in flashback)
- Papa Legba (Mentioned)
- Baron Samedi (Mentioned)
- Erzulie (Mentioned)
- Doctor Strange (Stephen Strange) (Only in flashback) (Cameo)
- Cable (Nathan Summers) (Only in flashback) (Cameo)
- Starfox (Eros) (Only in flashback) (Cameo)
- Wolverine (Logan) (Mentioned)
- Abyss Man (Francis)
- Gary Blood
- Unnamed Blood Brother (Mentioned)
- Guardians of the Galaxy
- Sui-San (Mentioned)
Races and Species:
- Humans
- Titans
- Zombies (Only in flashback)
- Loa (Mentioned)
- Asgardians
- Mutants (Mentioned)
- Celestials (Corpse, skeleton or other remains)
- Roclites
- Human-Spartax Hybrids
- Flora colossi
- Zen-Whoberis
Locations:
- Earth (Main story and flashback)
- Caribbean Sea (Main story and flashback)
- Saint Cynthia Island (First appearance) (Only in flashback)
- Malevolina Port (First appearance) (Only in flashback)
- Taíno Island (Main story and flashback)
- Latveria (Mentioned)
- Canada (Mentioned)
- Caribbean Sea (Main story and flashback)
- Somewhere Between Life and Death (Main story and flashback)
- Crossroads (Mentioned)
- Hell (Mentioned)
- Knowhere
- Realm of the Dead (Mentioned)
Items:
- Deadpool's Suit and Katanas (Main story and flashback)
- Doctor Doom's Armor (Only in flashback)
- Iron Man Armor Model 37 (Bleeding Edge Armor) (Only in flashback)
- Captain America's Uniform (Only in flashback)
- Captain America's Shield (Only in flashback)
- Mjolnir (Only in flashback)
- Infinity Gems (Mentioned)
Vehicles:
- Sanctuary (Main story and flashback)
Synopsis for "Part One: From Her to Eternity"
In the present, Thanos brutally beats up Deadpool while Death is watching. Thanos says that he will take back the gift of immortality he once gave to Wade.
A day prior on Saint Cynthia Island, Deadpool shoots Doctor Doom in the chest, only for him to rise again almost immediately. After being shot by Doom, Wade finds himself somewhere between life and death where he briefly sees Mistress Death in distress. It turns out that people all over the world have stopped dying. Deadpool decides to see Black Talon on Taíno Island about the situation. He does not know what is going on either, but he does reveal to Wade that he has been cursed by Thanos which leads Deadpool to the assumption that Thanos must have kidnapped Death. Therefore, Deadpool plans on rescuing and freeing Death.
Back in the present, Thanos explains that all things in the universe, except for Wade, no matter their fate will continue to live. Deadpool finds himself in a realm between life and death once more where he is encouraged by Death to restore balance to the universe. Meanwhile, Black Talon is asked by Abyss Man about Deadpool's whereabouts. At the same time, at Knowhere, the Guardians of the Galaxy hunt down Gary Blood.
Thanos finally realises that Death will not communicate with him, even with Deadpool out of the way. Wade agrees to help Thanos find her.
Solicit Synopsis
• We all know Thanos — the man who single-handedly made bejeweled gloves into THE deadly weapon of choice for mass murder. But did you know he shares an ex with Deadpool? No, not Vanessa — I refer to the cosmic “lady” known as DEATH.
• And when everyone in the universe stops dying, both of her former beaus take an interest. Can the pair overcome one’s overwhelming hatred of and annoyance by the other? Or will Thanos finally let Deadpool die once and for all?Notes
- Chronologically, these events happen sometime before Deadpool (Vol. 5) #1.