Extinction Gene

X-Men 116 page 11 panel 2


The Extinction Gene, E-Gene,[citation needed] or Extinction Sequence[1][2] is a hominid gene discovered by Doctor Hank McCoy in September 2001. According to him, it could turn on among the humans (Homo sapiens sapiens) and cause the extinction of the human race, in four generations; This race would be completely replaced by the mutants (Homo sapiens superior) because the number of this latter reached, at the beginning of the 21st century, a very important threshold.[3]

E for Extinction

Cassandra Nova thought that this gene was responsible for the disappearance of Neanderthals (Homo sapiens neanderthalis), thirty thousand years earlier, when they were replaced by the humans. Not wanting to see the disappearance of the whole of Humanity, she decided to commit the Genosha Genocide to decrease the number of mutants on Earth (of more than sixteen million people).[4]

Planet X

The argument of the Extinction Gene was later used by Xorn, impersonating Magneto, during his take-over of Manhattan.[2] In order to appease the relations between the humans and mutants, Henry McCoy presented himself to the U.S. President as the only one able to repair that gene and prevent humanity's extinction.[5]

Alternate realities

Here Comes Tomorrow (Earth-15104)


Dead-End Syndrome (House of M; Earth-58163)

In Earth-58163, the "Dead-End Syndrome" was a human distress condition who became prominent following the rise of mutantkind.[6]

Fan-speculation or unreferenced material

The Genosha genocide isn't seen to have been sufficient to prevent the release of the E-Gene.[citation needed] On the contrary, this release seemed to be prevented only by the transformation of millions of mutants into humans by the Scarlet Witch in December of 2005.[citation needed][7] Until the number of mutants rises again it is unclear if the E-Gene will reappear in the human genome.[citation needed]


  1. New X-Men #129
  2. 2.0 2.1 New X-Men #147
  3. New X-Men #116
  4. New X-Men #114
  5. New X-Men #150
  6. Secrets of the House of M #1; Stephen Strange's entry
  7. House of M #8

See Also

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