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In this universe, the Scarlet Witch said "No more humans" instead of "No more mutants", turning every human, except for ten percent of the population, into monsters.

Tony Stark who was in an outer-space mission during the House of M is a the tired, alcoholic leader of the remains of the humanity, and Captain America has been turned to a Deathlok by the spell.

Also this is a world where the Madri have special powers themselves, as they do in Earth-7153, but stay only between five and twenty second present.