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This is the reality for the DS version of the game Spider-Man: Web of Shadows.

It is presumed that this reality shares its history with Earth-616.

A symbiote invasion is underway and Spider-Man attempts to find Venom, who he believes responsible for the invasion. However, after fighting a myriad of symbiotes, and defeating Venom, he finds out that Venom was not responsible for the invasion.

Spider-Man, Venom