In this world, Magneto was attacked by Sentinels over Manhattan in 1979 (taking advantage of Marvel's sliding timescale policy, there are no heroes active in the 1970s). At the end of the attack, Magneto revealed an alleged international anti-mutant conspiracy involving Richard M. Nixon. The main result of this was that Magneto was granted sovereignty of the island of Genosha as the leader of the world's mutants. Another result was that the protection of mutant life was judged to be the foremost of all laws (as a result, stem cell research on mutant embryos is illegal, but stem cell research on altered human embryos is permitted). Because of this, the world is a racist society, with mutants controlling governments, businesses and culture, and Humans (or "Sapiens") are looked down on as inferior. (Essentially a reversal of the current status quo, where Homo sapiens are looked down on and despised instead of mutants).
Some exceptions apply to sapiens that live with privileges like Carol Danvers (Ms. Marvel) and Spider-Man. However, while Carol Danvers is widely known to be a sapien, Spider-Man is believed by the House of M world at large to be a mutant.
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- Red Guard