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In this reality, Peter Parker has been operating as Spider-Man for eight years. Assisted by NYPD Captain Yuri Watanabe, he helps combat crime in Manhattan. Following the fall of Wilson Fisk, the Kingpin of the underworld, the city was targeted by Mister Negative and his gang of Demons as part of a vendetta against Mayor Norman Osborn.

Following his initial defeat at the hands of Spider-Man with help from his partner and Daily Bugle reporter Mary Jane Watson, Mister Negative was broken out of the Raft and joined the plans of aggrieved scientist Doctor Octopus against Osborn, which involved the release of the plague known as Devil's Breath. In the process of tracking down an antidote for Devil's Breath, Spider-Man defeated some of his greatest foes, who had banded together as the Sinister Six, and restored order to the city by defeating countless of rioting Raft escapees. After defeating Doctor Octopus, a sample of the anti-serum in the villain's possession was used to synthesize more of it and restore the city to health.[1]

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