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The Cancerverse is a reality where life finally defeated Death. With eternal life being fueled by the Many-Angled Ones, every living being in this universe was corrupted and turned to their servitude, resulting in a universe-wide living corpse.

Following the launching of the T-Bomb by the Inhumans of Earth-616 and its subsequent detonation during a battle between that universe's Black Bolt and Vulcan, a breach (known as the Fault) was formed, creating a bridge to this corrupted universe. Several expeditions by entities of Earth-616 led to numerous encounters with the entities of the Cancerverse, including the Revengers and the Ex-Men (the Cancerverse versions of the Avengers and the X-Men, respectively).

Upon discovering the vast room to expand in that universe, the forces of the Cancerverse launched a campaign to invade Earth-616 and rid it of its concept of Death. Led by Lord Mar-Vell, the Cancerverse forces struck against the combined mighty of the Shi'ar, the Kree, the Nova Corps, and an assorted group of cosmic beings (including Galactus, Aegis, and Tenebrous); captured the anomalous Namorita, who had been saved by Nova during his brief encounter with the Sphinx; and looked for Thanos, the avatar of Death, so they could perform a ritual to destroy the abstract being. Meanwhile, the Guardians of the Galaxy invaded the Cancerverse alongside Thanos, fighting against numerous protectors of the Cancerverse, such as the Defenders, and briefly allying themselves with the last vestiges of good in this universe: the Machine Resistance, led by the Vision.

Discovering the avatar of Death to be in his home reality, Mar-Vell returned alongside the Revengers for a final confrontation with the Guardians and Thanos. After a short fight, Thanos submitted to Mar-Vell, begging to be killed by him. Mar-Vell then performed the ritual to destroy Death on Thanos, but ended up inadvertently summoning Death herself into the Cancerverse. Death then proceeded to kill many of the Cancerverse inhabitants and cripple their masters for aeons.[1] However, due to Death of Earth-616 not applying to this universe, the Cancerverse could not be destroyed.[2]