Bitterfrost was a top-secret Soviet installation for super-human and paranormal research. The base was devastated during a battle between the Hulk and the the Gremlin. During the Hulk's battle, S.H.I.E.L.D. fired its Contra-Energy Transversor (Designed by The Gaffer) and leveled the facility.
The base was rebuilt by The Gremlin. Iron Man launched an unauthorized attack on Bitterfrost to regain the technology that was stolen (or illegally acquired) by the Gremlin duirng his Armor Wars. Again, the base suffered much damage and the Gremlin appeared to perish in the conflict.
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