Anne Weying was Eddie Brock's ex-wife and a successful lawyer. Due to her close relation to his enemy, she assisted Spider-Man by sharing some of Eddie's history. When Spider-Man chased Venom into an amusement park and to find his parents, she followed. She confronted Eddie and managed to convince him to give up his vendetta. On another occasion, Sin-Eater shot Ann. To save her life, the alien symbiote temporarily bonded with her. She used her newly bonded being to attack her aggressors. Eddie saw her attack them and was afraid for and of her and compelled the symbiote back to him. Anne vomited upon seeing the pile of bodies she had left behind. She screamed, "That thing made me do that!" Eddie replied, "It can't make you do anything you don't really want to do." 
Later, the police incarcerated Ann on a false charge (unrelated to Ann's rampage above) in order to trap her husband, Venom. Ann used her one phone call to warn Eddie not to come. Venom promised that Eddie wouldn't and sent his symbiote through the phone lines to her. After it bonded with her she was able to free herself from prison.
Months later, Anne saw Spider-Man in an older black costume at a time when his regular red and blue suit had been stolen. She was still upset by the experience of bonding with the symbiote months earlier and unable to deal with the return of Eddie Brock into her life. This, coupled with Brock's transformation into Venom directly in front of her as he ran off to kill Spider-Man sent her over the edge, and she leapt from her high rise apartment to her death.
She-Venom possesses all the powers the original Venom has, including suit generated webbing, shape-shifting, super strength and an immunity to detection by Spider-Man's "spider-sense".
- Anne Weying first appeared in Amazing Spider-Man #375 and as "She-Venom," in Venom: Sinner Take All. She later appeared in every issue of Venom: Along Came a Spider and Rune vs. Venom.
- During the mini-series Venom: Dark Origin, Anne appears incorrectly depicted as a African-American woman.
- 23 Appearances of Anne Weying (Earth-616)
- 1 Minor Appearances of Anne Weying (Earth-616)
- Media Anne Weying (Earth-616) was Mentioned in
- 5 Images featuring Anne Weying (Earth-616)
- 2 Quotations by or about Anne Weying (Earth-616)
- Character Gallery: Anne Weying (Earth-616)
- Synopsis and Reviews of the Venom 2003 Series at Spiderfan.org
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