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Anna Coye was a friend of Miguel O'Hara. Miguel accompanied Anna to visit her sister Carrie who was admitted to ESU Hospital due to her degenerative genetic disease. While there there was an assault on the hospital by Mutagen who wanted to eliminate all genetic aberrations, so Miguel came out of Carrie's room with an excuse and transformed into Spider-Man to confront Mutagen, but during the fight, the two contenders broke through the ceiling of Carrie's bedroom knocking Anna out with the rubble. When Anna came to, the fight between Spider-Man and Mutagen was over and Anna found Carrie safe and sound.[1]

A few days later Anna and Miguel took a tour of Helix, a subsidiary of Alchemax, which had developed a prototype DNA scanner. During the tour, Mutagen stormed the Helix building with the intention of stealing the prototype so that he could easily find those people he considered genetic aberrations. During the assault, Mutagen recognized Anna and thought that since her sister had a genetic disease she too must have the same genetic disorder and was therefore intent on killing her; Miguel defended her but was hit by Mutagen when he was not yet transformed into Spider-Man so that Anna saw that Miguel could adhere to the walls. While trying to escape, taking advantage of the moment that Mutagen and Spider-Man were fighting, she was hit in the head by the rubble thrown by Mutagen that knocked her unconscious and when she awoke she discovered that she had suffered a head injury that had caused her a form of amnesia, thus not remembering the moments of Mutagen's attack and therefore also of Miguel's powers.[2]

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