Dissatisfied with the Ringmaster's leadership, she was responsible for him being thrown out and the Clown being declared their new leader When Spider-Man investigates the Circus of Crime and end up fighting them, one of the members, Princess Python runs away and Spider-Man tries to be a gentleman, not fighting a woman and instead pleads with her to surrender. While Spider-Man is knocked into her snake pit, the Ringmaster decides to get revenge and knocks the Clown out cold making his way out with the treasure. The Ringmaster was caught red-handed with paintings and the rest of the gang including Princess Python is rounded up by the police. .
She soon joined the Serpent Squad, but the Squad was defeated by Nomad. Princess Python rejoined the Circus of Crime until being recruited by Sidewinder for his Serpent Society. When the Society undertook a mission to assassinate MODOK, Princess Python panicked and fled the scene, coming across Captain America. Princess Python told him that she couldn't go through with the mission, as unlike the other serpents, she was just a snake charmer and had no powers or fighting skills. Captain America let her go, but the Society caught up with her. They expelled her from the Society, wiping her memory of their secrets. When her teammate Death Adder was delivering her to the Circus of Crime, his Serpent Saucer crashed and he flagged down a cab, leaving Princess Python in the saucer. The cab driver, however, turned out to be the Scourge, and killed Death Adder. Princess Python, who had been left behind, survived.