Shazana was the ruler of a nameless dimension which Dr. Strange had escaped to during a battle with Baron Mordo. She had usurped the throne from her half-sister with a timeless spell that she had learned from a magician that she had manipulated into aiding her. She was defeated when Dr. Strange destroyed her source of power, a sort of power crystal, which she had hidden under her own throne.
She later resurfaced in Nevada where she possessed Trish Starr who had joined a commune in the desert and had developed an obsession with mysticism and the occult. When Starr went missing for several days her friends at the commune contacted her ex-boyfriend Kyle Richmond and Shazana's old enemy, Doctor Strange. The two men succeeded in finding Trish, but unwittingly released Shazana who no longer depended on her power crystal for her mystical powers. She contained Strange, Nighthawk and Trish in a cube constructed of their own life energies. Strange, however, still managed to contract the rest of the Defenders who arrived in time to help defeat Shazana before she could take Trish's life. This time, Strange sent Shazana back to her nameless dimension and created a dimensional barrier to keep her from menacing the Earth again.