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Marie was an orphan living in Cologne, Germany in the mid 18th century. She was adopted by a kindly old priest named Father Eisner who took her in and raised her as his own. In 1753, Marie was present when Father Eisner and a band of villagers captured and executed the vampire lord known as Dracula. After Eisner drove a stake into Dracula's chest, he fell over from a heart attack. Eisner was taken back to his home, but Marie knew that the only father she had ever known would surely die. That evening, she sneaked into the town square and removed the stake from Dracula's chest. Dracula sought to repay Marie's efforts by drinking her blood, but she was protected by the crucifix which hung about her neck. Marie recalled Dracula's boasts of being "life everlasting" and made a bargain with him. If he would agree to bestow the gift of immortality upon the dying Father Eisner, then he could do whatever he wished with Marie. Dracula agreed, but rather than save Eisner's life, he instead tore his heart from his chest and presented it to Marie as a demonstration of his vile power. He then attacked her again, but Marie dangled her cross charm in front of Dracula's face, forcing him to flee. Dracula swore, that one day she would beg him to give her life everlasting.[citation needed]

By 1823, Marie Eisner, nearing the end of her life, was residing at the Reichenbach Clinic. As promised some seventy years earlier, Dracula arrived at her room, seeking to turn her into a vampire. He wanted the frail old woman to acknowledge him as her savior, but Marie rebuked him. Enraged, Dracula lunged to attack her, but Marie slipped her crucifix necklace about the vampire's neck, forcing him to recoil. Marie then passed away without ever knowing the touch of the vampire.[citation needed]

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Marie Eisner did not possess any superhuman capabilities.

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