Henri Le Pym was a natural philosopher and scientist who was coerced and blackmail by Baron Victor Octavius into finding a cure for the Baron's octopus/hybrid state as his shrunken wife Janette was under hostage. And also for the Baron to offer Pym in helping to unshrinking his wife. Pym used the blood of witchbreeds, including his colleague Hal McCoy, in formulating his concoctions for the Baron. In his experiments, Pym required the use of illegal dinosaur eggs from the New World, in which was brought in by Peter Parquagh.

Pym was then confronted by a sickly Norman Osborne, who was infected with gangrene and requested his help in return for helping Pym acquire some of Peter's blood for his experiments. After Peter was captured, Pym extract a sample from Peter's blood. Though, it was not enough when French officers came to arrest him and Octavius. In the confusion after McCoy was set freed, Pym escape with Octavius and managed to extract the needed blood for his elixir for Octavius. However, Pym only discover that Octavius had finally progress into his final form and became mad, believing that he is superior over mankind. Pym's work was purposely spilled over by Octavius and worse to see his wife had been further mutated by Octavius into a human/wasp hybrid. Pym licked what little use of his elixir and attacked Octavius, but to be overpowered and thrown into Venice's canals. Moments later when Octavius had the advantage over the Spider, Pym emerges as a giant due from licking the elixir and took revenge on Octavius by stepping on the Baron. Thus killing him. After bidding goodbye to the Spider, Henri and Janette travels back to one of Pym's lab in France, where he will use his own blood to manufacture a cure for the couple.

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Henri Le Pym (Earth-311)

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