Hathor-Sekhmet first appeared under the guise of the 'Lion God'. He sought knowledge of the Panther God, so he captured the Black Panther in order to learn his secrets. The Lion God chose to go to Avengers Mansion and threaten the Black Panther with the Avengers' lives on the line, if he would not talk. A fight soon followed, and Thor was able to summon some lightning and smite the Lion God.
After his initial defeat, the Lion God watched the Avengers and waited for a chance to strike. He got it when Mantis and Swordsman summoned him directly into Avenger's Mansion. As the Lion God was getting ready to burn Black Panther at the stake, Swordsman and Mantis distracted him. This gave Iron Man the chance to trap him inside some Adamantium.
Sekhmet would later encounter again Thor accompanied by the Prince of Power of the time Amadeus Cho some time after as her true form, but during the confrontation she would be tricked into consuming a sedative by Cho. Pacified she would revert into Hathor and proceed to affectionately flirt with Thor. The drug would eventually wear off, and Sekhmet would get to take out her anger against Vali Halfling. Sekhmet was also one of the goddesses that along with the Elder Goddess Gaea would collect the Young Gods to be presented to the Celestials Fourth Host as a means to bring a favorable judgement to Earth and humanity.