Hathor-Sekhmet first appeared under the guise of the 'Lion God'. He sought knowledge of the Panther God, so he captured the Black Panther in order to learn his secrets. The Lion God chose to go to Avengers Mansion and threaten the Black Panther with the Avengers' lives on the line, if he would not talk. A fight soon followed, and Thor was able to summon some lightning and smite the Lion God.
After his initial defeat, the Lion God watched the Avengers and waited for a chance to strike. He got it when Mantis and Swordsman summoned him directly into Avenger's Mansion. As the Lion God was getting ready to burn Black Panther at the stake, Swordsman and Mantis distracted him. This gave Iron Man the chance to trap him inside some Adamantium.