The Goblin formula, additionally known as the OZ formula is a biogenic chemical compound made to augment the human body. After Norman Osborn had his business partner, Mendel Stromm, arrested for embezzlement he found in his notes a formula which could apparently augment a person’s body to superhuman levels. Norman began research on the formula, hoping to eventually sell it. Unknown to him his son had tampered with it to spite him. Consequentially the completed formula was unstable and exploded in Norman's face. He spent the next week in the hospital recovering. After finally regaining consciousness he found his mental and physical functions have been greatly enhanced. It was later learned that exposure also causes severe insanity which was the primary motivation for Norman taking the identity of the Green Goblin.
Spider-Man Films (Earth-96283)
Norman Osborn and he team created a human performance-enhancer for the military. After exposing himself to the experimental Oscorp performance-enhancing process, Norman underwent the same transformation as the earlier animal test subjects. He gained superhuman strength and durability as well as improved dexterity. Earlier tests suggested that the process increased strength over 800% but it was even more efficacious for Norman, who could punch Spider-Man hard enough to knock him back over two dozen feet with enough momentum to fell a metal lightpost that crossed his path and allowed him to suspend the weight of a cable car full of passengers with one hand. His improved reflexes and agility allowed him to easily defeat numerous police officers in hand-to-hand in a few seconds and to match the swiftness and acrobatic prowess of Spider-Man. Unfortunately for Norman, the same process also rendered him insanely violent and aggressive. These psychotic urges manifested as a new identity, the "Green Goblin".
Ultimate Universe (Earth-1610)
For years, after the successful creation of Captain America, the government always wanted to recreate the Super Soldier Serum for military applications. Since the original serum was lost, the government has contracted private firms to help re-discover the serum, including OsCorp. Utilizing the blood of Nick Fury (the first actual successful super soldier and Rogers second) as a template, OsCorp created an prototype serum called Oz.
OZ was created by OsCorp CEO Norman Osborn. OsCorp has since fallen on difficult financial times and the Oz Project was meant to save both his company and his seat on the board. Like any prototype drugs, Oz was injected into lab experiment animals to observe their reactions, including a series of spiders that mutated because of it.
Peter Parker had a tour of OsCorp and was accidentally bitten by one of the escaped lab spiders labelled OZ Experiment Arachnid No. 42. The spider's venom mixed with Oz and created a variant of Oz that successfully created Spider-Man; Oz worked. With OsCorp on the verge of collapse, Osborn tested Oz on himself, believing he had the necessary data he needed to recreate Spider-Man upon himself; it created Green Goblin instead. A flame-powered reptilian-like creature with a savage mind.
Harry Osborn would also later become victim to Oz and became the Hobgoblin. Unknown to many, the spider that bitten Parker wasn't the only Oz-mutated spider, there was actually a series of them. After the destruction of OsCorp, the lab spiders mutated by Oz was left by their own devices and one of them ended up biting Miles Morales, creating a second Spider-Man. 
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The Goblin Formula makes people insane and aggressive.
- 23 Appearances of Goblin Formula
- 4 Media Goblin Formula was Mentioned in
- 1 Images featuring Goblin Formula
- Item Gallery: Goblin Formula
- Fan-Art Gallery: Goblin Formula
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