A drug addict named "Freak" is chased down by Spider-Man after he attempted to steal from the poor at the soup kitchen Spider-Man's Aunt May works at. He stumbles into a laboratory owned by Curt Connors and injects himself with animal gene fluids, thinking they were crystal meth. Freak then began to form a chrysalis around his body, emerging as a skinless monster. After being shot at by police, he falls into the sewer and forms another chrysalis. Emerging as an animal hybrid, and completely bulletproof, Freak tracks Spider-Man by his scent after killing a hot-dog seller. After a violent confrontation, Freak gives in to his addictions, and finds a meth lab. Spidey follows him, and during the ensuing fight, the building is set ablaze. Freak is caught under the flaming debris, but survives and creates a new chrysalis, which has made him fireproof and even stronger. Freak emerges as an armadillo-like creature, and again tries to kill Spider-Man. When Connors arrives with the quicklime necessary to incapacitate Freak, Spider-Man tricks him into thinking Connors has drugs. Freak tears open the bags, and is covered in the quicklime. He again forms a chrysalis, with Spider-Man pouring quicklime over it, to permanently incapacitate him. The chrysalis is taken by a hazmat crew, which is later revealed to be an Oscorp research group.
Freak is next seen cut open and hooked up to machines in an Oscorp lab where scientists are using his unique abilities to cure various diseases. Norman Osborn injects him with a sample of the Anti-Venom antibodies to create "super-venom," a virus capable of killing millions with a single drop. He then uses the super-venom to re-power Mac Gargan who was "cured" of his symbiote by Anti-Venom. Norman also mentions that Freak is incapable of becoming high now because his body adapted to his drug addiction by removing the pleasure center of his brain. In the confrontation between Spider-Man and Osborn, Osborn activates the building's self-destruction, with Freak still inside. A search afterwards by Oscorp found "no signs of life", which made the team reason that Freak was killed, with Osborn immediately retorting "Idiot. Think about it for a second."