Nothing about her past is known, or how she obtained the purse that gives her "super-powers". At one point in her life, Honey was approached by the Japanese organization that created the country's first super-hero team known as Big Hero Six. She was offered to join the team and accepted.
She became seemingly attracted to the team's newest potential recruit, Hiro Takachiho, as she kept smiling at him flirtatiously. Later, Honey helped overthrow a menace called Everwraith and saved Japan from destruction.
She was only briefly seen afterward, helping Sunfire out in Canada. Sometime later, a mysterious individual used a machine to mind-control the entire team of Big Hero Six, including Honey Lemon. They were send to Canada once again, where they fought the newest incarnation of Alpha Flight until Sasquatch discovered the plot. Honey Lemon was, along with of the rest of the team, brought back to normal and they all returned to Japan to discover who mind-controlled them.